Product Name: Turinover

Active substance: Chlorodehydromethyltestosteronum

Therapeutic actions:
Turinover (4-chloro-1-dihydro-17-alpha-metiltestosteron) is considered to be a steroid for oral administration mainly anabolic properties of reduction of androgen. Thus, it is considered that the androgenic activity is 6%, and the anabolic 53%. Compared to Turinover Metandrostenolon has a 45% share of anabolic androgenic 90%. Turinover, as androgenic and anabolic steroids, penetrates cell membranes and interact with cytoplasmic receptors and the complex formed is transported to the nucleus where it acts on specific nuclear receptors. Active complex binds to DNA and to act as a transcription factor that causes the synthesis of RNA and protein specific.
Turinover mainly show anabolic, which is particularly evident in skeletal muscle and bone and other tissues with high splitting (bone marrow, mucosa and so on). Preparation first determines muscle growth and growth rate (less effect as testosterone, but can be amplified when used with other anabolic). The bones help fixing calcium in bones, possibly due to increased formation of protein matrix or reduction in parathyroid hormone responsiveness of bone tissue. A key contribution lies in achieving anabolic metabolic changes: a positive nitrogen balance (nitrogen retention), increased protein synthesis, decrease catabolism of amino acids, phosphorus and potassium retention. The drug stimulates hematopoiesis, especially erythropoiesis (erythropoietin formation increases) and favors leucopoiesis and platelet formation. Turinover is a derivative of Metandrostenolon which has been placed in position 4 an atom of chlorine (4-chloro-1-dihydro-17 alpha-methyl testosterone). This change kept available for internal management but are subject to first pass metabolism. An important feature of the preparation is the lack of transformation in the estrogen metabolism as no supine flavoring.

Indication:
Protein synthesis disorders, cachexia diverse genesis, trauma, extensive burns after irradiation infectious diseases, muscular dystrophy, osteoporosis, negative nitrogen balance corticosteroid therapy, hypo-and aplastic anemia.

Turinover as prepared predominantly anabolic effect can be indicated as adjunctive therapy. In cases of protein catabolism with negative nitrogen balance (deficiency, consumption or loss of protein). In the elderly with severe denutrition and cachexia, in asthenia, cachexia different origin in combustion vast and bedsores, after surgery, infections and major trauma, osteoporosis, long-term use of glucocorticoids, hypo-and aplastic anemia, chronic hemolytic anemia, anemia of chronic renal failure, anemia caused by tumors, lymphomas and leukemia , idiopathic thrombocytopenia, muscle atrophy in patients with AIDS in pediatric practice in case of increasing retention, anorexia (lack of appetite), weight reduction.

Contraindications and Cautions:
Hypersensitivity to the drug, prostate cancer and adenoma, breast cancer in men, breast carcinoma in women with hypercalcemia, ovarian, CPI, severe atherosclerosis, nephritis, nephrotic syndrome, hepatic and renal function, acute and chronic prostatitis, pregnancy, lactation period until sexual maturation. When prescribing steroids anabolic patients should be informed about the possible side effects with your doctor immediately, address their occurrence. At the first signs of virilization of patients (deepening of the voice, hirsutism, acne, clitoromegalie) administration should be stopped to avoid irreversible changes.

Preparations of this group can cause suppression of plasma coagulation factors II, V, VII, X that requires careful supervision, including concomitant use with indirect anticoagulants.
During treatment, it is necessary to monitor liver function parameters (transaminases, alkaline phosphatase, bilirubin) and lipid (cholesterol and low density lipoproteins). The elderly may find an increased incidence of hypertrophy and prostate carcinoma requiring close supervision.
In children anabolicelor steroid use requires caution because they may accelerate epiphyseal closure areas, an effect that may last for 6 months after suspension. For these reasons, it is recommended to consult with specialists about the rationality of using a control preparation radiological bone maturation.
In patients using high doses of anabolic steroids is periodic determination of hemoglobin and hematocrit because of possible polycythemia.

Side Effects:
Liver disorders: cholestatic jaundice, rare hepatocytes with hepatic necrosis, hepatocellular neoplasms. You can change the biochemical parameters: increase the level of bilirubin, alkaline phosphatase, transaminases. Cholestatic jaundice may develop after 6 weeks or more of treatment (home is considered to be toxic) and is manifested by capillary bile stasis with hyperbilirubinaemia and increased alkaline phosphatase content. Prolonged use for many years may increase the frequency of liver tumors.

Endocrine disorders: Turinover rarer than other anabolic in men can cause: reduced spermatogenesis and sexual potency (secondary decrease gonadotropins and testosterone secretion with testicular atrophy and oligospermia) prostate hypertrophy (mainly in older patients), epididymitis, chronic priapism. Boys may cause early sexual maturation, frequent erections, increasing retention risk.
The women can cause: inhibition of gonadotropin secretion, acts of virilization (acne, hirsutism, deepening of the voice, increased libido, menstrual irregularities, clitoral hypertrophy, muscle development). In pregnant women can cause fetal virilization. Turinover frequency of these adverse effects is small.
Neurological disorders: excitation, insomnia, depression, confusion.
Metabolism: reduced glucose tolerance, increase the level of low density lipoproteins (LDL), accelerated phase creatinine level, edema due to sodium and water reabsorption, retention, potassium, calcium, phosphorus. In people long attached to the bed can be found hypercalcemia.
Miscellaneous: during puberty may close early epiphyseal areas with increased retention.

Dosage:
Therapy with anabolic steroids is adjunctive and can not substitute for basic treatment. Duration Turinover use the patient's response is addictive and the development of possible side effects.
Adults: anabolic steroid response is varied. Turinover adult dose of 20-50 mg per day is. Length is considered appropriate cure time of 2-6 weeks.

Interactions:
Glucocorticoids, Mineralocorticoids, corticotropin preparations containing sodium and sodium-rich foods enhances fluid retention in the body, increasing the risk of developing edema, acne eruptions intensify.
The concomitant use of indirect anticoagulants anabolic increase concentration and effects of which concerned the dose reduced. Monitoring is necessary to decide on further treatment with anabolic or suspension. It is necessary to monitor the prothrombin time.
The concomitant use of ACTH and corticosteroids in patients with edema, which may be increased, but the probability is very low. Anabolic steroids decreases the level globulin coupled with the decline in the total thyroxin T4 and increased T3 and T4 uptake. Free fraction of thyroid hormone levels remain unchanged. Radioactive iodine intake capacity is preserved.

Additional:
Store in a dry place protected from light, at a temperature of 15-25 ° C. Keep out of reach of children.