Product Name: Restaver
Active substance: Testosterone Undecanoate
Restaver comprises testosterone undecanoate, which is an ester of natural testosterone. After the introduction of Restaver, testosterone undecanoate is gradually released from the depot and is broken down by esterases serum testosterone and undecanoic acid. Restaver effect on the body is identical to the action of endogenous testosterone.
Testosterone - the male sex hormone that is required for the formation and maintenance of androgen functions. Synthesized in the testes and to a lesser extent, in the adrenal cortex. Testosterone provides the formation of reproductive organs of male type, the development of secondary sexual characteristics, the maintenance of the male phenotype, androgen-dependent functions, spermatogenesis and other functions in the skin, muscles, bones, kidneys, liver, bone marrow and central nervous system. Depending on the target organ is the androgenic effects of testosterone (prostate, seminal vesicles, epididymis) and anabolic (muscle, bone, blood system, kidneys, liver). In some organs, the action of testosterone is shown after its peripheral conversion to estradiol which binds to estrogen receptor in the nuclei of target cells (the pituitary, adipose tissue, brain, bones, in testicular Leydig cells).
Insufficient secretion of testosterone leads to a male hypogonadism, which is characterized by low serum testosterone concentrations. Symptoms of male hypogonadism include: a weakening of erection, impotence, decreased libido, fatigue, depression, hypoplasia or regression of secondary sexual characteristics, decreased muscle mass and strength, increased risk of osteoporosis.
Restaver assigned to improve the deficient endogenous levels of testosterone and decrease the symptoms of hypogonadism, as in the "classical" hypogonadism and age with androgen deficiency in men. In men suffering from hypogonadism use Restaver decreases fat mass, increase muscle mass, prevent bone loss and osteoporosis, can improve sexual function and provide positive psychotropic effect.
Restaver is the first drug for the treatment of hypogonadism in men, which is used 1 time in 3 months (4 intramuscular injections per year). One injection of Restaver maintains testosterone levels within the physiological limits within 3 months, with no pathological increase and decrease. Increasing serum testosterone over baseline observed on the next day after the first injection and reaches Restaver physiological values after 3 days.
An important advantage of Restaver for the patient is the rapid onset of effect and duration of action that allows you to not depend on the need for frequent reference to the doctor. On the other hand, assigning Restaver, the doctor an opportunity to regularly (every 3 months) to monitor the patient's condition, which is particularly important at the beginning of testosterone therapy. This greatly increases the safety of the treatment compared with drugs that patients use their own, for many months (or even years) did not appear at the doctor for monitoring and correction of treatment.
It's safe to say that Restaver is practically useless for bodybuilders. Now the drug is used only to maintain libido in recovery cycle, when due to a drop in testosterone levels in the blood and reduces the sex drive.
Contraindications and Cautions:
- Androgen-dependent prostate carcinoma;
- Androgen-dependent carcinoma of the breast in men;
- Hypercalcemia, concomitant malignant tumors;
- Tumors of the liver in the present or in history;
- Hypersensitivity to the drug.
Restaver not applicable in women.
Caution should be used on patients with sleep apnea syndrome.
Because the drug is still an ester of testosterone, it is characterized by all of the side effects of the steroid with the amendment that due to the low bioavailability of the drug they are much less pronounced.
A typical daily dosage of the drug is 240 (6 capsules) and 480 (12 capsules) mg. The daily dose of testosterone undecanoate be divided into three equal parts. Testosterone undecanoate is perhaps the only one of testosterone esters that can be used in women with no risk. Dosage - 120-240 mg per day.
In the period between cycles is useful to combine the reception of testosterone undecanoate with receiving oxandrolone.
The drug should be stored out of reach of children at temperature not exceeding 25 ° C. Shelf life - 5 years.